Publications

2025

Schlemm E, Gauthier S, Magnus T, Thomalla G, Rosa-Neto P, Woo MS. Risk of amyloid-related imaging abnormalities associated with anticoagulant therapy in patients with Alzheimer’s disease treated with anti-amyloid monoclonal antibodies: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2025 Dec 25;jnnp-2025-337386. 

Woo MS, Macedo AC, Hosseini SA, Therriault J, Wang Y, Rahmouni N, Aumont É, Servaes S, Tissot C, Fernandez‐Arias J, Trudel L, Hall B, Bezgin G, Quispialaya‐Socualaya K, Goncalves M, Chan T, Stevenson J, Zheng Y, Hopewell R, Mitchell S, Lussier FZ, Vitali P, Massarweh G, Soucy J, Benedet AL, Gauthier S, Zetterberg H, Blennow K, Pascoal TA, Rosa‐Neto P. APOE ɛ4 carriership determines a faster plasma p‐tau217 progression in Aβ‐positive individuals. Alzheimer’s Dement. 2025 Dec 26;21(12).

Woo MS, Brand J, Bal LC, Moritz M, Walkenhorst M, Vieira V, Ipenberg I, Rothammer N, Wang M, Dogan B, Loreth D, Mayer C, Nagel D, Wagner I, Pfeffer LK, Landgraf P, van Ham M, Mattern KMJ, Winschel I, Frantz N, Sonner JK, Grosshans HK, Miguela A, Bauer S, Meurs N, Müller A, Binkle-Ladisch L, Salinas G, Jänsch L, Dieterich DC, Riedner M, Krüger E, Heppner FL, Glatzel M, Puelles VG, Engler JB, Nyengaard JR, Misgeld T, Kerschensteiner M, Merkler D, Meyer-Schwesinger C, Friese MA. The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis. Cell. 2025 Aug;188(17):4567-4585.e32.

Woo MS, Therriault J, Seyyed Ali Hosseini, Yi-Ting Wang, Macedo AC, Rahmouni N, Aumont É, Servaes S, Tissot C, Fernandez-Arias J, Trudel L, Hall B, Bezgin G, Quispialaya-Socualaya K, Goncalves M, Chan T, Stevenson J, Zheng Y, Mitchell S, Hopewell R, Pola I, Tan K, Molfetta G Di, Lussier FZ, Massarweh G, Vitali P, Soucy JP, Gauthier S, Ashton NJ, Blennow K, Pascoal TA, Zetterberg H, Benedet AL, Rosa-Neto P. Glia inflammation and cell death pathways drive disease progression in preclinical and early AD. EMBO Mol Med. 2025

Schmidt C*, Woo MS*, Alimy AR, Baranowsky A, Krasemann S, Yorgan TA, Beil FT, Schinke T, Keller J, Friese MA, Amling M, Rolvien T. Biphasic bone loss in experimental autoimmune encephalomyelitis. J Bone Miner Res. 2025 Apr 21;40(4):522–34. *Contributed equally

Aumont E, Therriault J, Kwan ATH, Carello-Collar G, Arfaie S, Hall BJ, Ferrari-Souza JP, Woo MS, Macedo AC, Tissot C, Trudel L, Rahmouni N, Servaes S, Vitali P, Soucy J, Pascoal TA, Zimmer ER, Gauthier S, Rosa-Neto P. The Evolution of Randomized Clinical Trial Designs to Assess Therapeutics in Alzheimer Disease. JAMA Netw Open. 2025 Aug 29;8(8):e2529665.

Schubert C, Schulz K, Sonner JK, Hadjilaou A, Seemann AL, Gierke J, Vieira V, Meurs N, Woo MS, Lohr C, Morellini F, Hirnet D, Friese MA. Neuroinflammation causes mitral cell dysfunction and olfactory impairment in a multiple sclerosis model. J Neuroinflammation. 2025 Mar 8;22(1):71.

Trudel L, Therriault J, Macedo AC, Woo MS, Rahmouni N, Aumont É, Servaes S, Hosseini SA, Ferrari-Souza JP, Bellaver B, Ferreira PL, Chan T, Wang YT, Fernandez-Arias J, Zheng Y, Hall B, Stevenson J, Hopewell R, Hsiao CHH, Montembeault M, Klostranec J, Iturria-Medina Y, Vitali P, Karikari TK, Benedet AL, Ashton NJ, Zimmer E, Gauthier S, Pascoal TA, Zetterberg H, Blennow K, Rosa-Neto P. APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s disease. Commun Med. 2025 Nov 20;5(1):484.

Krieg K, Materna-Reichelt S, Naber T, Rachad FZ, Kauven P, Weller A, Haferkamp U, Wittich A, Zaliani A, Woo MS, Walkenhorst M, Siegmund M, Harberts J, Zierold R, Blick R, Conze C, Muschong P, Miltner D, Friese MA, Mezler M, Siegmund H, Evert K, Krasemann S, Gužvić NS, Klein CA, Werner-Klein M, Wegener J, Pless O. Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs. Cell Reports Methods. 2025 Nov;101236

Lorenz SM, Wahida A, Bostock MJ, Seibt T, Santos Dias Mourão A, Levkina A, Trümbach D, Soudy M, Emler D, Rothammer N, Woo MS, Sonner JK, Novikova M, Henkelmann B, Aldrovandi M, Kaemena DF, Mishima E, Vermonden P, Zong Z, Cheng D, Nakamura T, Ito J, Doll S, Proneth B, Bürkle E, Rizzollo F, Escamilla Ayala A, Napolitano V, Kolonko-Adamska M, Gaussmann S, Merl-Pham J, Hauck S, Pertek A, Orschmann T, van San E, Vanden Berghe T, Hass D, Maida A, Frenz JM, Pedrera L, Dolga A, Kraiger M, Hrabé de Angelis M, Fuchs H, Ebert G, Lenberg J, Friedman J, Scale C, Agostinis P, Zimprich A, Vogt-Weisenhorn D, Garrett L, Hölter SM, Wurst W, Glaab E, Lewerenz J, Popper B, Sieben C, Steinacker P, Zischka H, Garcia-Saez AJ, Tietze A, Ramesh SK, Ayton S, Vincendeau M, Friese MA, Wigby K, Sattler M, Mann M, Ingold I, Jayavelu AK, Popowicz GM, Conrad M. A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis. Cell. 2025 Dec

2024

Woo MS*, Mayer C*, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024 Jul;187(15):4043-4060.e30. *Contributed equally

Woo MS, Tissot C, Lantero‐Rodriguez J, Snellman A, Therriault J, Rahmouni N, Macedo AC, Servaes S, Wang Y, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Benedet AL, Ashton NJ, Karikari TK, Triana‐Baltzer G, Kolb HC, Stevenson J, Mayer C, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa‐Neto P. Plasma pTau‐217 and N‐terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid‐β positive individuals. Alzheimer’s Dement. 2024 Feb 3;20(2):1166–74.

Woo MS*, Therriault J*, Jonaitis EM, Wilson R, Langhough RE, Rahmouni N, Benedet AL, Ashton NJ, Tissot C, Lantero-Rodriguez J, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Betthauser TJ, Lussier FZ, Hopewell R, Triana-Baltzer G, Kolb HC, Jeromin A, Kobayashi E, Massarweh G, Friese MA, Klostranec J, Vilali P, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Johnson SC, Rosa-Neto P. Identification of late-stage tau accumulation using plasma phospho-tau217. eBioMedicine. 2024 Nov;109:105413. *Contributed equally

Therriault J*, Woo MS*, Salvadó G*, Gobom J, Karikari TK, Janelidze S, Servaes S, Rahmouni N, Tissot C, Ashton NJ, Benedet AL, Montoliu-Gaya L, Macedo AC, Lussier FZ, Stevenson J, Vitali P, Friese MA, Massarweh G, Soucy JP, Pascoal TA, Stomrud E, Palmqvist S, Mattsson-Carlgren N, Gauthier S, Zetterberg H, Hansson O, Blennow K, Rosa-Neto P. Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology. Mol Neurodegener. 2024 Jan 7;19(1):2. *Contributed equally

Woo MS*, Bal LC*, Winschel I, Manca E, Walkenhorst M, Sevgili B, Sonner JK, Di Liberto G, Mayer C, Binkle-Ladisch L, Rothammer N, Unger L, Raich L, Hadjilaou A, Noli B, Manai AL, Vieira V, Meurs N, Wagner I, Pless O, Cocco C, Stephens SB, Glatzel M, Merkler D, Friese MA. The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis. J Clin Invest. 2024 Aug 15;134(16). *Contributed equally

Woo MS, Engler JB, Friese MA. The neuropathobiology of multiple sclerosis. Nat Rev Neurosci. 2024 Jul 24;25(7):493–513.

Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martínez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK, Jonaitis E, Brum W, Tissot C, Servaes S, Rahmouni N, Macedo AC, Stevenson J, Fernandez-Arias J, Wang YT, Woo MS, Friese MA, Jia WL, Dumurgier J, Hourregue C, Cognat E, Ferreira PL, Vitali P, Johnson S, Pascoal TA, Gauthier S, Lleó A, Paquet C, Petersen RC, Salmon D, Mattsson-Carlgren N, Palmqvist S, Stomrud E, Galasko D, Son SJ, Zetterberg H, Fortea J, Suárez-Calvet M, Jack CR, Blennow K, Hansson O, Rosa-Neto P. Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability. Nat Aging. 2024 Nov 12;4(11):1529–37.

Wang YT, Ashton NJ, Servaes S, Nilsson J, Woo MS, Pascoal TA, Tissot C, Rahmouni N, Therriault J, Lussier F, Chamoun M, Gauthier S, Brinkmalm A, Zetterberg H, Blennow K, Rosa-Neto P, Benedet AL. The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer’s disease. Transl Neurodegener. 2024 May 28;13(1):27.

Binkle-Ladisch L, Pironet A, Zaliani A, Alcouffe C, Mensching D, Haferkamp U, Willing A, Woo MS, Erdmann A, Jessen T, Hess SD, Gribbon P, Pless O, Vennekens R, Friese MA. Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity. iScience. 2024 Dec;27(12):111425.

Winschel I, Willing A, Engler JB, Walkenhorst M, Meurs N, Binkle-Ladisch L, Woo MS, Pfeffer LK, Sonner JK, Borgmeyer U, Hagen SH, Grünhagel B, Claussen JM, Altfeld M, Friese MA. Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis. Biol Sex Differ. 2024 May 15;15(1):41.

Walkenhorst M, Sonner JK, Meurs N, Engler JB, Bauer S, Winschel I, Woo MS, Raich L, Winkler I, Vieira V, Unger L, Salinas G, Lantz O, Friese MA, Willing A. Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis. Nat Commun. 2024 Oct 28;15(1):9287.

Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo MS, Friese MA, Lohr C, Grochowska KM. Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling. Glia. 2024 Aug 17;72(8):1451–68.

Schell M, Mayer C, Woo MS, Leischner H, Fischer M, Grensemann J, Kluge S, Czorlich P, Gerloff C, Fiehler J, Thomalla G, Flottmann F, Schweingruber N. Fluid excess on intensive care unit after mechanical thrombectomy after acute ischemic stroke is associated with unfavorable neurological and functional outcomes: An observational cohort study. Eur Stroke J. 2024 Aug 16.

Schweingruber N, Bremer J, Wiehe A, Mader MMD, Mayer C, Woo MS, Kluge S, Grensemann J, Quandt F, Gempt J, Fischer M, Thomalla G, Gerloff C, Sauvigny J, Czorlich P. Early prediction of ventricular peritoneal shunt dependency in aneurysmal subarachnoid haemorrhage patients by recurrent neural network-based machine learning using routine intensive care unit data. J Clin Monit Comput. 2024 Oct 21;38(5):1175–86.

2023

Woo MS, Nilsson J, Therriault J, Rahmouni N, Brinkmalm A, Benedet AL, Ashton NJ, Macedo AC, Servaes S, Wang YT, Tissot C, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Karikari TK, Stevenson J, Mayer C, Ferrari-Souza JP, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P. 14-3-3-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2. J Neuroinflammation. 2023 Nov 24;20(1):278.

Woo MS, Shafiq M, Fitzek A, Dottermusch M, Altmeppen H, Mohammadi B, Mayer C, Bal LC, Raich L, Matschke J, Krasemann S, Pfefferle S, Brehm TT, Lütgehetmann M, Schädler J, Addo MM, Schulze zur Wiesch J, Ondruschka B, Friese MA, Glatzel M. Vagus nerve inflammation contributes to dysautonomia in COVID-19. Acta Neuropathol. 2023 Sep 15;146(3):387–94.

Woo MS*, Ufer F*, Sonner JK, Belkacemi A, Tintelnot J, Sáez PJ, Krieg PF, Mayer C, Binkle-Ladisch L, Engler JB, Bauer S, Kursawe N, Vieira V, Mannebach S, Freichel M, Flockerzi V, Vargas P, Friese MA. Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells. Sci Adv. 2023 Sep 22;9(38). *Contributed equally

Woo MS*, Mayer C*, Fischer M, Kluge S, Roedl K, Gerloff C, Czorlich P, Thomalla G, Schulze zur Wiesch J, Schweingruber N. Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit. Neurol Res Pract. 2023 May 4;5(1):17. *Contributed equally

Woo MS*, Mayer C*, Brehm TT, Andersen G, Weigel A, Löwe B, Lohse AW, Addo MM, Gerloff C, Knobloch JKM, Schulze zur Wiesch J, Friese MA. Absence of self-reported neuropsychiatric and somatic symptoms after Omicron variant SARS-CoV-2 breakthrough infections. Brain Commun. 2023 Mar 2;5(2):1–13. *Contributed equally

Woo MS*, Brehm TT*, Fischer M, Heyer A, Wichmann D, Jordan S, Nörz D, Lütgehetmann M, Addo MM, Lohse AW, Schmiedel S, Kluge S, Schulze zur Wiesch J. Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study. Jhaveri TA, editor. Microbiol Spectr. 2023 Feb 14;11(1). *Contributed equally

Mayer C*, Woo MS*, Brehm TT, Heyer A, Fischer M, Fischbach F, Bal LC, Addo MM, Kluge S, Thomalla G, Schweingruber N, Schulze zur Wiesch J. History of cerebrovascular disease but not dementia increases the risk for secondary vascular events during SARS‐CoV‐2 infection with presumed Omicron variant: a retrospective observational study. Eur J Neurol. 2023 Aug 25;30(8):2297–304. *Contributed equally

Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes‐Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR. Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer’s disease. EMBO J. 2023 Feb 15;42(4).

Brehm TT, Heyer A, Woo MS, Fischer M, van der Meirschen M, Wichmann D, Jarczak D, Roedl K, Schmiedel S, Addo MM, Lütgehetmann M, Christner M, Huber S, Lohse AW, Kluge S, Schulze zur Wiesch J. Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study. J Infect Public Health. 2023 Nov;16(11):1806–12.

2022

Woo MS*, Kessner SS*, Schlemm E, Gerloff C. Atraumatic spinal needle indicates correct CSF opening pressure. Sci Rep. 2022 Dec 6;12(1):21089. *Contributed equally

Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, Wagner I, Haferkamp U, Pless O, Merkler D, Engler JB, Friese MA. G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis. Sci Adv. 2022 Aug 5;8(31).

Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A, Moese S, Müller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Reports. 2022 Jan;11(2):578–92.

2021

Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA. Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. J Exp Med. 2021 May 3;218(5).

Woo MS, Haag F, Nierhaus A, Jarczak D, Roedl K, Mayer C, Brehm TT, van der Meirschen M, Hennigs A, Christopeit M, Fiedler W, Karagiannis P, Burdelski C, Schultze A, Huber S, Addo MM, Schmiedel S, Friese MA, Kluge S, Schulze zur Wiesch J. Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19. iScience. 2021;24(7):102752.

Zhang XW, Huck K, Jähne K, Cichon F, Sonner JK, Ufer F, Bauer S, Woo MS, Green E, Lu K, Kilian M, Friese MA, Platten M, Sahm K. Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma. Oncoimmunology. 2021 Jan 14;10(1).

2020

Woo MS, Malsy J, Pöttgen J, Seddiq Zai S, Ufer F, Hadjilaou A, Schmiedel S, Addo MM, Gerloff C, Heesen C, Schulze Zur Wiesch J, Friese MA. Frequent neurocognitive deficits after recovery from mild COVID-19. Brain Commun. 2020;2(2):1–9.

Woo MS, Steins D, Häußler V, Kohsar M, Haag F, Elias-Hamp B, Heesen C, Lütgehetmann M, Schulze zur Wiesch J, Friese MA. Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients. J Neurol. 2020 Jul 11;(0123456789):1–3.

Montes-Cobos E, Huscher B, Engler JB, Woo MS, Binkle L, Bauer S, Kursawe N, Moles M, Friese MA, Ufer F. Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells. J Immunol. 2020;205(11):3001–10.

Hermann J, Bender M, Schumacher D, Woo MS, Shaposhnykov A, Rosenkranz SC, Kuryshev V, Meier C, Guse AH, Friese MA, Freichel M, Tsvilovskyy V. Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons. Front cell Dev Biol. 2020;8:496.

2019

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA. Bassoon proteinopathy drives neurodegeneration in multiple sclerosis. Nat Neurosci. 2019 Jun 22;22(6):887–96.